This animated YouTube video, created by Southwest Center for Microsystems Education (SCME), illustrates how DNA hybridization works in the context of nanofabrication. The animation and associated narration describe "DNA hybridization is when a single-stranded DNA (ssDNA) molecule bonds with a complementary ssDNA molecule from another source forming a "hybrid". This animation shows a double-stranded DNA (dsDNA) molecule dividing into two ssDNA strands. One ssDNA remains on the substrate as the "probe". A complementary ssDNA from another source (a ssDNA with a complementary base pair sequence) joins with the probe forming a 'hybrid' dsDNA molecule." A supporting learning module and activities can be downloaded from the SCME website.